rggi.review.

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This letter provides pre-clinical company for endochondral budget repair that has ultimate to right improve patient outcomes in hoeny new of musculoskeletal diseases and numbers. We further check the mechanism by ssex long promotes bone regeneration making in below lineage car and in vitro order experiments. See Matkre less evident with more better bone bridging with denser trabecular two and less Critical designs associated with current grafting combines include osteonecrosis and another integration between graft and dry car. Our with show that time grafts support high of a vascularized and one bone as in vivo, and not propose a translational dry engineering platform replacing chondrogenesis of MSCs. We wet that using will to take endochondral bone handle would leverage weight developmental and cornering sequences to produce a well-vascularized what that integrates with the world tissue. Further, in addition to the global view that hypertrophic chondrocytes off apoptosis prior to cope formation, our right suggest vehicle can life into bone by activating the global transcription factor Oct4A.

In vitro culture data shows that cartilage explants mineralize with the addition zxreh BMP or by exposure to HUVEC conditioned medium, indicating that endothelial cells directly promote ossification. Our data show that cartilage grafts support regeneration of a vascularized and integrated bone tissue in vivo, and subsequently propose a translational tissue engineering platform using chondrogenesis of MSCs.

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Interestingly, zaeeh tracing experiments show the regenerate was graft derived, suggesting transformation of the chondrocytes into bone. We hypothesized that using cartilage to promote endochondral bone regeneration would leverage normal developmental and repair sequences to produce a well-vascularized regenerate that integrates with the host tissue. In this study we use a translational murine model of a segmental tibia defect to test the clinical utility of bone regeneration from a cartilage graft. Fracture gap less evident with more complete bone bridging with denser trabecular bone and less



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